اثرات هیستو پاتولوژیکی نیتریت سدیم بر سرخرگ کلیوی موش صحرایی

Background and purpose: Nitrite is the material used in industry for storing food specially sausage and ham. Fast foods which contain high levels of nitrite are widely eaten throughout the world. Nitrite is also found in water, soil and ecosystem, and could highly influence human’s health. This study was performed to examine the histopathological effect of sodium nitrite on renal artery in rats. Materials and methods: This study included 60 adult male and female Wistar rats, divided into six groups of 10. They were examined for 60 days, and were assigned into the following groups: 175 mg/kg/day dose recipient group, 350 mg/kg/day dose recipient group and control group which absorbed nitrite through drinking water. At the end of day 60, after anesthesia blood sample was collected from the heart. The arteries were taken out of the body, then tissue sections were prepared to identify the tissue changes. The samples were stained with Hematoxilin Eozin method and thickness of intima media was measured with image tool software. In both sexes, we checked morphometric and morphologic features of the arteries, body weight changes before and after the test and blood NOx level. The data was then analyzed using SPSS ver. 17. Results: The outcome of NOx plasmatic density measurement showed that NOx level significantly increased in animal ’s blood in 175 mg/kg/day dose recipient group and 350 mg/kg/day dose recipient group compared with the control group (P≤ 0.05). Also, in both sexes the thickness of media layer decreased significantly in the 350 mg/kg/day dose recipient group. Conclusion: According to the results, nitrite in different dose could increase the amount of blood NOx and renal artery intima media thickness could reduce by 350 mg/kg sodium nitrite. Existence of nitrite in foods can cause vascular problems in consumers, therefore, it could be considered as a threatening factor in vascular system.